J Anal Res Clin Med. 2015;3(2):118-125.
doi: 10.15171/jarcm.2015.018
  Abstract View: 600
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Original Research

Comparison of levetiracetam versus phenytoin for seizure prophylaxis in patients with traumatic brain injury: A meta-analysis

Ali Meshkini 1, Morteza Ghojazadeh 2, Ardalan Golbahar-Haghighi 3 * , Vahideh Zarea-Gavgani 4, Sepideh Lotfi-Sadigh 3

1 Professor, Road Traffic Injury Research Center, Department of Neurosurgical Sciences, Imam Reza Teaching Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
2 Associate Professor, Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Student of Medicine, School of Medicine, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
4 Assistant Professor, Department of Medical Library and Information Science (DMLIS), School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Introduction: Phenytoin (PHT) is used for seizure prophylaxis in patients with traumatic brain injury (TBI). However, levetiracetam (LEV) is emerging as an alternative. Hence in this study, we aimed to conduct a meta-analysis comparing these two drugs in patients with TBI. Methods: A systematic search in electronic databases was performed. Studies consistent with our purpose (comparing LEV vs. PHT for the prevention of seizures in TBI patients) were selected for our meta-analysis. We extracted data of all eligible studies on a standard abstraction sheets. Extracted data included patient’s demographics, study type, intervention, and outcome. We defined seizures as primary outcome. Results: 1184 unduplicated papers identified by our search of which 1106 were excluded by reading the abstract and titles. 72 papers were removed by reading the full text. Finally 6 studies (Cohort studies) were selected for analysis. There is no superiority of either these two drugs at preventing of seizures based on the point estimate’s odds ratio (OR) = 1.1 [95% confidence interval (CI) = 0.55-2.20]. Conclusion: PHT and LEV showed equal efficacy in prevention of seizures after TBI
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Submitted: 07 Nov 2014
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