J Anal Res Clin Med. 2015;3(4):231-235.
doi: 10.15171/jarcm.2015.036
  Abstract View: 475
  PDF Download: 361

Original Research

Growth hormone deficiency in cleft lip and palate patients

Shahin AbdollahiFakhim 1, Gholamreza Bayazian 2 * , Siamak Shiva 3, Mojtaba Sohrabpour 4, Younes Ebrahimzade 4

1 Associate Professor, Pediatric Research Center, Koodakan Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
2 Assistant Professor, Hazrat Rasoul Hospital, Iran University of Medical Sciences, Tehran, Iran
3 Associate Professor, Department of Pediatrics, School of Medicine, Koodakan Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
4 Resident, Department of Otolaryngology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Introduction: Failure to thrive (FTT) is relatively common among cleft patients, most commonly attributed to feeding problems during the first months of life. Close association between midline clefts and pituitary gland abnormalities prompted us to determine the frequency of growth hormone deficiency in cleft patients, which is easily treated.
Methods: Any cleft patient with FTT was studied and when the patient’s height was under the 3rd percentile of normal, growth hormone was checked after clonidine administration. Growth hormone was checked before and 30, 60 and 90 minutes after clonidine use.
Results: Of 670 patients with cleft lip or palate, 31 patients (4%) had some kind of growth retardation according to weight, height or head circumstance. Eighteen patients were under the 3rd percentile of normal height. Growth hormone deficiency was detected in 8 patients out of 18 patients and overall frequency of growth hormone deficiency among cleft patients with growth retardation was 25.8% (8 out of 31). Seven patients of 8 were male whereas one was female and half of the patients were syndromic.
Conclusion: Cleft patients have many problems with normal feeding and all kind of support should be provided to achieve near-normal feeding and they should be monitored for normal growth. Any patient with growth retardation, especially height decrease, should be assessed for growth hormone deficiency.
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Submitted: 10 Jul 2015
Accepted: 27 Sep 2015
First published online: 30 Nov 2015
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