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J Anal Res Clin Med. 2015;3(4):219-224.
doi: 10.15171/jarcm.2015.034
  Abstract View: 1005
  PDF Download: 809

Original Research

Relationship between severity of depression symptoms and iron deficiency anemia in women with major depressive disorder

Seyed gholamreza Noorazar 1, Fatemeh Ranjbar 2, Negin Nemati 3, Neda Yasamineh 4, Parinaz Kalejahi 5 *

1 Assistant Professor, Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
2 Associate Professor, Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
3 General Practitioner, Petroleum Industry Health Organization, Tabriz. Iran
4 Resident, Department of Prosthodontics, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
5 MSc Student, Department of Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Introduction: Iron deficiency (ID) is a common nutritional problem lead to many unintended consequences such as decrease energy, immune system problems, and neurological dysfunction. The most common psychological disorder is depression. A patient with ID anemia (IDA) show signs and symptoms of behavioral and mood disorders like depression. Methods: In this study, 100 female patients with diagnosed major depression in years 2010 and 2011 were studied. In all patients standard Hamilton depression rating scale (HDRS) was used to evaluate depression severity. Blood samples were taken for complete blood count difference analysis and evaluating anemia and in those with hemoglobin (Hb) < 12 mg/dl, ferritin, and total iron binding capacity were checked to evaluate IDA. Results: Patients mean age was 36.34 ± 10.43 years old. Mean HDRS score was 32.20 ± 4.07. 19 had anemia, and among them 8% had IDA. Mean HDRS score in patients with IDA (33.37 ± 1.90) was higher than those without (32.09 ± 4.19), but the difference was not significant (P = 0.39). There was no difference between patients with and without anemia in HDRS score. The negative relation was observed between Hb levels, and HDRS score (Pearson correlation = -0.21, P = 0.03). Conclusion: We observed that the negative correlation between Hb levels and HDRS score. It demonstrates the effect of Hb decrease and anemia occurrence on depression severity; however, it needs more studies.
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Submitted: 27 May 2015
Accepted: 13 Oct 2015
First published online: 30 Nov 2015
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