J Anal Res Clin Med. 2016;4(4):233-237.
doi: 10.15171/jarcm.2016.039
  Abstract View: 611
  PDF Download: 620

Case Report

A Case of Solitary Neurofibroma in Outer Surface of Nose

Shahin Abdollahi-Fakhim 1, Saman Rezaeian 2, Hojjat Hosseinpour-Feizi 3, Mohammad Naghavi-Behzad 4, Reza Piri 5 *

1 Associate Professor, Department of Ear, Nose and Throat (ENT), School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2 Resident, Department of Ear, Nose and Throat (ENT), School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 Associate Professor, Department of Orthopedics Surgery, Shohada Educational Medical Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
4 Student of Medicine, Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
5 Student of Medicine, Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Solitary neurofibroma is a benign tumor originating from Schwann cells in peripheral nerves. In an investigation of 430000 pathologic samples, only 6 cases of neurofibroma had been reported in nose and paranasal sinuses. Present patient was a 15-year-old girl with left-sided nasal and malar mass, whose CT scan and MRI showed a non-circumscribed solid mass with total thickness affecting outer part of nose in left side as well as surface and deep soft tissue. The mentioned mass underwent excision by sub-labial incision and open rhinoplasty keeping infra-orbit nerve intact. Pathologic investigation of samples showed adipose fibroblast and skeletal muscle fibers with proliferation of spindle-shaped cells and staining was negative for GFAP and positive for S-100 which represents diagnosis of neurofibroma. Main differential diagnoses of benign tumors of paranasal sinuses and nasal cavity include neurofibroma, fibroma, leiomyomas, papilloma, and schwannoma. After resection tumor should be precisely monitored, since there is malignant transformation possibility in solitary neurofibromas.
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Submitted: 20 May 2016
Accepted: 18 Jun 2016
First published online: 06 Aug 2016
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