J Anal Res Clin Med. 2018;6(4):153-157.
doi: 10.15171/jarcm.2018.025
  Abstract View: 24
  PDF Download: 26

Original Article

Association of serum immunoglobulin G level with peritonitis in patients undergoing peritoneal dialysis: An analytical study

Sima Abedi Azar 1 ORCiD, Mohammad Reza Jafari Nakhjavani 2, Niousha Kalami 3, Tala Pourlak 4, Behnaz Ghamari 2, Farid Karkon Shayan 5 * ORCiD

1 Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran
5 Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Introduction: Peritonitis is one of the most common complications of peritoneal dialysis. On the other hand, reduced levels of immunoglobulins (Igs), mainly IgG, can increase the risk of infection in various pathologic conditions. Here, we aimed to determine the association of severity and frequency of peritonitis with serum IgG levels in peritoneal dialysis patients. Methods: 100 patients with chronic renal failure referred to Imam Reza Hospital, Tabriz, Iran, for peritoneal dialysis were included in the study. Serum IgG levels were measured in all of these patients at the beginning of the study and after six months of follow-up. In case of peritonitis, serum IgG levels were also measured, and samples were sent to Imam Reza Hospital laboratory for analysis. Results: 40 cases (40%) were women, and 60 cases (60%) were men with a mean age of 47 years. 24 cases (24.0%) had at least one episode of peritonitis during the study. Among those with peritonitis, 14 cases (60.9%) had at least one more peritonitis episode in the 6-month follow up. The mean serum IgG levels were 1079 mg/dl and 429 mg/dl at the beginning and after six months of follow up, respectively. The difference was shown to be statistically significant (P = 0.006). There was no correlation between serum IgG level reduction and peritonitis in these patients (P > 0.999). Conclusion: This study found reduced levels of serum IgG in patients undergoing peritoneal dialysis. However, it was not associated with increased risk of peritonitis in these patients.
First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 24

Your browser does not support the canvas element.


PDF Downloaded: 26

Your browser does not support the canvas element.

Submitted: 24 Jan 2018
Accepted: 12 Mar 2018
First published online: 15 Dec 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)